Genetic study in patients operated dentally and anesthetized with articaine-epinephrine

Aims: In this study we wanted to figure out if there was a correlation between OPRM1 N40D, TRPV1 I316M, TRPV1 I585V, NOS3 −786T>C and IL6 −174C>G polymorphisms and the response to locally applied articaine-epinephrine anesthetic. Methods: In this observational study, 114 oral cell samples of patients anesthetized with articaine-epinephrine (54 from men 60 from women), were collected from dental centers in Madrid (Spain). High molecular weight DNA was obtained from oral mucosa cells. The analysis of OPRM1 N40D (rs1799971), TRPV1 I316M (rs222747), TRPV1 I585V (rs8065080) and IL6 −174C>G polymorphism was performed through real-time PCR allelic discrimination using TaqMan probes. Polymorphism NOS3 −786T> C (rs2070744) was analyzed using RFLP-PCR. Results: The studied polymorphisms are involved neither in the response to the anesthetic, nor in the intensity of perceived dental pain. However, in a subset of female patients we found that TRPV1 I316M was associated with a delayed onset of anesthesia. Conclusions: There is no association among these polymorphisms and the time elapsed between the application of the anesthetic and the onset of its effect

In situ surface coverage analysis of RuO₂-catalysed HCl oxidation reveals the entropic origin of compensation in heterogeneous catalysis

In heterogeneous catalysis, rates with Arrhenius-like temperature dependence are ubiquitous. Compensation phenomena, which arise from the linear correlation between the apparent activation energy and the logarithm of the apparent pre-exponential factor, are also common. Here, we study the origin of compensation and find a similar dependence on the rate-limiting surface coverage term for each Arrhenius parameter. This result is derived from an experimental determination of the surface coverage of oxygen and chlorine species using temporal analysis of products and prompt gamma activation analysis during HCl oxidation to Cl2 on a RuO2 catalyst. It is also substantiated by theory. We find that compensation phenomena appear when the effect on the apparent activation energy caused by changes in surface coverage is balanced out by the entropic configuration contributions of the surface. This result sets a new paradigm in understanding the interplay of compensation effects with the kinetics of heterogeneously catalysed processes

Uveítis y glaucoma asociados a infección por Hepatozoon canis : reporte de un caso

ABSTRACT: We report the case of a five years old German Shepherd dog, who presented anterior uveitis in his left eye which then led him to glaucoma and corneal ulcer. Clinical examination found a patient with low body condition, muscle weakness, dull and brittle coat, and unspecific symptomatology. During both the cell blood count (CBC) and blood smears, gamonts of Hepatozoon canis were found in blood and aqueous humor. Diagnosis, treatment and progress are reported.RESUMEN: Se expone el caso de un perro Pastor Alemán de cinco años y medio de edad, el cual presentó uveítis anterior en ojo izquierdo que luego le condujo a glaucoma y úlcera corneal. En el examen clínico se encontró un paciente con baja condición corporal, debilidad muscular, además de un pelaje opaco y quebradizo, con sintomatología inespecífica. Tanto en el hemograma como en los extendidos sanguíneos se encontraron gamontes de Hepatozoon canis en sangre y humor acuoso. Se discute su diagnóstico, tratamiento y evolución

Noncommutative 6D Gauge Higgs Unification Models

The influence of higher dimensions in noncommutative field theories is considered. For this purpose, we analyze the bosonic sector of a recently proposed 6 dimensional SU(3) orbifold model for the electroweak interactions. The corresponding noncommutative theory is constructed by means of the Seiberg-Witten map in 6D. We find in the reduced bosonic interactions in 4D theory, couplings which are new with respect to other known 4D noncommutative formulations of the Standard Model using the Seiberg-Witten map. Phenomenological implications due to the noncommutativity of extra dimensions are explored. In particular, assuming that the commutative model leads to the standard model values, a bound -5.63 10^{-8} GeV^{-2}< theta <1.06 10^{-7}GeV^{-2} on the corresponding noncommutativity scale is derived from current experimental constraints on the S and T oblique parameters. This bound is used to predict a possibly significant impact of noncommutativity effects of extra dimensions on the rare Higgs boson decay H-> gamma gamma.Comment: Latex file, 11 pages, 1 figur

Actividades intersectoriales en la prevención de accidentes de tráfico

ResumenSe describen las líneas de trabajo priorizadas y algunos resultados obtenidos en la implantación del programa de prevención y reducción de lesiones por accidentes de tráfico en un área de salud. A partir de 1999 el Centro de Salud Pública priorizó la identificación y búsqueda de aliados en otros sectores (Asociación de policías locales y educación), la construcción de la capacidad de trabajo conjunta y la formación de un grupo intersectorial. Se llevaron a cabo actividades docentes y jornadas. Se formó una red de personas en 17 de un total de 39 ayuntamientos que participan con actividades en el grupo intersectorial. Un total de 10 de estos ayuntamientos participaron con actividades educativas y siete, además, exigieron al cumplimiento de la legislación.El grupo intersectorial potenció la visibilidad de sus actividades a través de los medios de comunicación local. Estas actividades no están dirigidas a reducir las lesiones por tráfico, sino a crear un marco de trabajo para la movilización de los sectores implicados. Se pretende potenciar más el compromiso entre los niveles políticos, técnicos y civiles incidiendo en valores sociales de respeto para una vida más saludable.AbstractWe describe priority issues and some of the results obtained from the implementation of the «Prevention and Reduction of Traffic Accident Injuries» program in a health area. Since 1999 the public health center has made a priority of identifying and recruiting partners from other sectors (the local police association and the local education authority), increasing its capacity for working together, and setting up an intersectorial working group. Teaching activities and meetings were held. A network of people was created from 17 of a total of 39 town halls that participate in activities supported by the intersectorial group. Ten are involved in educational activities and a further seven focus on ensuring compliance with the law. The intersectorial group promoted their visibility through the local media. These activities are not aimed at reducing injuries from road traffic accidents, but rather at creating an action framework through which all the sectors involved can be mobilized. The aim is to strengthen commitment among political, technical and civil sectors by focussing on social values of respect for a healthier life

The Feynman effective classical potential in the Schr\"odinger formulation

New physical insight into the correspondence between path integral concepts and the Schr\"odinger formulation is gained by the analysis of the effective classical potential, that is defined within the Feynman path integral formulation of statistical mechanics. This potential is related to the quasi-static response of the equilibrium system to an external force. These findings allow for a comprehensive formulation of dynamical approximations based on this potential.Comment: 10 pages, 4 figure